49ers LB Dre Greenlaw loses appeal, will sit vs. Commanders
San Francisco loses a linebacker to suspension and expects to be without a receiver for a couple of weeks with a hamstring injury.

Let's go through the film on the week's 49ers news, because two key players are going to be out of the lineup, and that's worth talking through.
Greenlaw's appeal is denied
The lead item: linebacker Dre Greenlaw will serve his one-game suspension Monday night against the Commanders. Per ESPN, the NFL rejected his appeal Tuesday, so the penalty stands as handed down.
Per ESPN, the league suspended Greenlaw one game without pay for unsportsmanlike conduct in Sunday's game against the Seahawks. ESPN's report says the issue was a head-butt on a Seattle linebacker who had lost his helmet.
Here's what to watch. A linebacker is the traffic cop of a defense. He gets the calls, fits the run and keeps everyone lined up. When one of those players is out, the whole front has to communicate differently, and that takes practice reps this week. The bigger question is who handles that responsibility and how smoothly the group adjusts. That's a teaching moment for the coaching staff, and for Greenlaw too. A one-game absence hurts the whole unit, which is why composure matters.
Samuel out with a hamstring
The other piece of news is on offense. Per ESPN, receiver Deebo Samuel hurt his hamstring Sunday in Seattle, and coach Kyle Shanahan said Monday that Samuel is expected to miss at least a couple of weeks.
Hamstrings are tricky. They tend to linger when a player comes back too fast, so a patient timeline like the one Shanahan laid out is the kind of caution you want to see. Without Samuel, the other receivers and the play-callers will have to find ways to replace that production. Expect the staff to lean on the healthy players and to emphasize clean execution on the routine plays. Winning the small battles, like getting open on time and finishing blocks, is how a team covers for an injury.
Bottom line
Put the two items together and the Niners head into a Monday night game with a linebacker unavailable and a receiver on the mend. Neither looks like a season-wrecker based on what's been reported, but both are real tests of depth. Teams that handle weeks like this usually do it with preparation, discipline and next-man-up effort, and that's what to look for against the Commanders.
Sources
- Niners LB Dre Greenlaw's appeal of suspension rejected, will sit vs. Commanders
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